摘要
本文采用免疫组化ＳＰ法检测４８例胰腺癌和１５例胰腺癌转移灶石蜡标本中ｂｃｌ－２、ｐ５３、ｃ－ｍｙｃ的表达。结果显示：ｂｃｌ－２蛋白在胰腺癌组明显高于胰癌转移灶组；无转移的、高分化的胰腺癌明显高于有转移的和低分化胰腺癌。ｐ５３蛋白在胰腺癌组明显高于胰腺良性病变组，胰腺高分化癌明显低于胰腺低分化癌。ｂｃｌ－２和ｐ５３蛋白在胰腺癌组中呈负相关。
In this study , the expression of bcl-2 , p53 , c-myc in 48 pancreatic cancer and 15 pancreatic cancer metastases was detected by SP method. The positive expression rate of bcl-2 protein in carcinoma group was higher than that in the metastasis one,and that in non-metastatic , highly-differentiated pancreatic cancer was higher than that in the metastatic,low-differentiated carcinoma. The positive expression rate of p53 protein in cancer group was higher than that in the benign alteration one , and that in metastasis group was higher than that in the carcinoma one ; pancreatic highly- differentiated cancer was lower than the low differentiated cancer , In pancreatic carcinoma group, a inverse correlation was found between bcl-2 and P53 protein.
