血液透析过程中TGF-α水平变化及临床意义的探讨

SIGNIFICANCE OF TRANSFORMING GROWTH FACTOR-α SERUM LEVEL CHANGES DURING HOMEDIALYSIS

探讨血液透析(HD)对血清及尿液中转化生长因子α(TGF-α)含量变化的影响采用放射免疫分析法,对49例维持性HD患者血清及12小时尿液进行TGF-α的水平检测,以30例健索人作为对照,结果与对照组比较,HD前TGF-α水平明显降低(p<0.01)。与HD前比较,HD后TGF-α水平增高十分显著(p<0.05)12小时尿液中TGF-α水平明显高于对照组,具显著性差异(p<0.05),使用铜仿膜与聚枫膜透析器的患者血清TGF-α水平明显高于醋酸纤维膜与血仿膜组。TGF-α水平明显改变参与了HD患者的发病机理及病理生理过程。

To explore effect of Homedialysis on the chage of TGF-α content in serum and urine. Method The levels of transforming growth factor-α in serum and urine specimens of 45 patients maintained on HD were determined with RIA and levels in 30 healthy people used as the control. Results (1) The levels of serum TGF-α in patients before HD were significantly lower than those in the controls (p<0.01). After HD, the serum levels were much higher than pre-HD levels (p<0.05). (2) Average level of TGF-α in patients'12hr urine was significantly higher than that of the controls (p<0.05). (3) Post-HD levels of serum TGF-α. in patients with copropnonc and polyculfone as the dialysis membrane were higher than those in patients using cellulose acetaite and hemophane.Conclusion Serum TGF-α levels usualy increased after HD. wich was thought to be beneficial to the patient in someway requiring further study. The increase was especially marked with copropnonc or polyculfone.