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Infliximab联合免疫球蛋白治疗噬血细胞综合征疗效观察 被引量：1

Clinical observation on therapeutic effect of infliximab and immunoglobulin on patient with hemophagocytic lymphohistiocytosis
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摘要 目的:观察抗肿瘤坏死因子单克隆抗体(infliximab)联合免疫球蛋白治疗噬血细胞综合征疗效。方法:大剂量免疫球蛋白(10 g/d×4 d)联合2次Infliximab(100mg/d)。结果:1例有多个脏器功能损害的患者诊断为柯萨奇病毒感染合并噬血细胞综合征,治疗后病情完全缓解。结论:噬血细胞综合征本身只是一种过度免疫反应,infliximab可能成为阻断细胞因子的重要治疗手段。 Objective：to observe the therapeutic effect of infliximab and immunoglobulin on the patient with hemophagocytic lym- phohistiocytosis （HLH）.Methods：Infliximab（100mg/day） was administered twice and immunoglobulin （10 g/d×4 d） was administered.Results ： A 20-year-old woman diagnosed with HLH,attained remission.Conclusion： For HLH patients, anticytokine treatment with infliximab may represent one of promising options.
作者 周慷 娄世峰 陈林
机构地区 重庆医科大学附属第二医院血液科
出处 《现代医药卫生》 2010年第7期976-978,共3页 Journal of Modern Medicine & Health
关键词 噬血细胞综合征 INFLIXIMAB 肿瘤坏死因子 Hemophagocytic lymphohistiocytosis Tumor necrosis factor-α（TNF-α） infliximab
分类号 R5 [医药卫生—内科学]
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参考文献8

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同被引文献36

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现代医药卫生
2010年 第7期

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