老年慢性阻塞性肺疾病患者常见病原菌分布及耐药性分析

Analysis of drug-resistance and pathogenic bacteria distribution in elderly patients with chronic obstructive pulmonary disease

目的:分析老年慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者临床病原菌分布及耐药性,为临床合理使用抗菌药物提供科学依据。方法:对602份COPD患者痰标本进行细菌培养鉴定及药物敏感实验。结果:检出的403株细菌中,革兰阳性球菌占13.4%,革兰阴性杆菌占60.3%,铜绿假单胞菌占首位。药物敏感性实验显示,病原菌对抗菌药物存在不同程度的耐药性;对碳青霉烯类、糖甙类药物敏感性最高。结论:革兰阴性杆菌为老年COPD患者的主要致病菌,临床上应重视多重耐药问题,根据药敏结果合理选择抗生素。

Objective：To analyze the pathogenic bacteria distribution and drug-resistance from chronic obstructive pulmonary discase（COPD） and to provide the scientific basis for clinical using antibiotics rationally.Methods：The bacteria from 602 sputum samples in the patients with COPD were cultured and identified, and the drug. sensitivity tests were performed.Results：Among the 403 strains isolated from COPD, Gram-positive cocci were 13.4% ,Gram-negative bacterial 60.3%.Pseudomonsa aeruginosa occupied the first position.The results of antibiotic susceptibility tests showed that the bacteria had different drug-resistance, and the most sensitive antibiotics were still carbopenems and glycosides.Conclusion：Gram-negative bacteria are the main infections pathogens in COPD, so attention should be paid to the increasing of multi-drug resistance in clinic and select antibiotics correctly according to the test of drug-resistance.