他汀类药物治疗80例高脂血症的疗效观察

Therapeutical effect observation of statins on hyperlipidemia in 80 cases

目的:观察阿托伐他汀与辛伐他汀治疗高血脂症的疗效与不良反应。方法:80例高脂血症患者随机分为A、B两组,在常规低脂膳食基础上,A组服用阿托伐他汀20 mg,B组服用辛伐他汀20 mg,日1次,疗程8周。检测两组患者治疗前及治疗后8周的血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、肌酸激酶(CK)的变化。结果:服药8周末与治疗前相比:两组的TC、TG、LDL-C均显著下降(P<0.01),HDL-C均明显上升(P<0.05),但以A组更为显著。结论:阿托伐他汀和辛伐他汀均为高效、安全的降脂药物,但阿托伐他汀的降脂效果更为显著。

Objective ：To investigate the efficacy and adverse reactions of atorvastatin and simvastatin in treatment of hyperlipidemia. Methods：80 cases of hyperlipidemia were randomly divided into A and B groups.Based on the conventional low-fat diet, A group was treated with atorvastatin 20 mg,B group was treated with simvastatin 20mg,both once daily for 8 weeks.In two groups before and after treatment,the changes of serum total cholesterol （TC）, triglyceride （TG）,low-density lipoprotein cholesterol （LDL-C） and high-density lipoprotein cholesterol （HDL-C）, alanine amino - transferase （ALT）,aspartate aminotransferase （AST）, creatine kinase （CK）were investigated.Results：Comparlng after g-week medication with those before treatment,TC ,TG, LDL-C were significantly decreased in both two groups （P 〈0.01）, HDL-C were significantly increased （P〈0.05）, but the A group was more prominent.Conclusion：Atorvastatin and simvastatin are effective and safe lipid-lowering drugs, but atorvastatin cholesterol-lowering effect is more noticeable.