原发性高血压肾病患者尿微量白蛋白和血清胱抑素C水平检测的临床意义

Clinical significance of determination of urine microalbumin and serum cystatin C levels in patients with primary hypertension nephropathy

目的:探讨原发性高血压肾病患者尿微量白蛋白和血清胱抑素C水平的变化及意义。方法:应用免疫比浊法和ELISA法对36例原发性高血压肾病患者进行尿微量白蛋白和血清胱抑素C水平测定,并与30例正常健康人作比较。结果:原发性高血压肾病患者尿微量白蛋白和血清胱抑素C水平均明显高于正常人组(P<0.01),且两者呈明显正相关(r=0.5921 P<0.01)。结论:检测原发性高血压肾病患者尿微量白蛋白和血清胱抑素C水平的变化对了解病情和观察愈后均具有重要的临床价值。

Objective：To explore the clinical significance of determination of urine microalbumin and serum cystatin C levels in the patients with primary hypertension nephropathy.Methods：Urine microalbumin levels （with immunoturbidimetry）and serum cystatin C levels （with ELISA） were determined in 36 patients with primary hypertension nephropathy and 30 controls.Results：Urine microalbumin and serum cystatin C levels in the patients with primary hypertension nephropathy were significantly higher than those in controls （P〈0.01）. Urine mieroalbumin and serum cystatin C levels were mutually positively correlated （r=0.5921 P〈0.01）.Conclusion：Urine microalbumin and serum cystatin C levels were closely related to the diseases process of primary hypertension nephropathy and have important prognostic values.