肺癌分子靶向治疗的研究进展

Research Progress of Molecular Targeted Therapy for Lung Cancer

目的:总结国内外对肺癌分子靶向治疗的研究进展.方法:应用检索MEDLINE及CHKD期刊全文数据库检索系统,以"肺癌和靶向治疗"为关键词,检索1995～2007年有关文献.结果:肺癌是目前世界上发病率和死亡率最高的恶性肿瘤,经手术、放疗和化疗等综合治疗后,其5年生存率仍低于15%.肺癌的发病机制十分复杂,其发生、发展和转移与多种基因突变、细胞信号传导通路和新生血管增生异常密切相关,这正是采用分子靶向治疗的理论基础和潜在靶点.结论:分子靶向治疗正逐渐被医学界所重视,并成为21世纪肺癌治疗最具希望的方法和策略.

Objective： To summarize the research progress of molecular targeted therapy for lung cancer at home and abroad. Methods： Application of MEDLINE retrieval system and CHKD journal Full-text Database（CJFD） system, we research the relevant literatures from 1995 to 2007 with ＂lung cancer and targeted therapy＂ as keywords. Results： Lung cancer is currently the world＇s highest morbidity and mortality disease in malignant tumors. After surgery, radiotherapy, chemotherapy and other comprehensive treatment, its 5-year survival rate is still below 5%. The pathogenesis of lung cancer is very complex. Its occurrence, development and transfer are closely related with a variely of gene mutalions, cell signal transduction pathways and neovaseularization, and this is precisely the theoretical basis and potential target for molecular targeted therapy. Conclusion： Molecular targeted therapy is getting more and more attention by medical field, and become the most promising approach and strategy for lung cancer treatment in 21 st century.