磷酸川芎嗪佐治毛细支气管炎的临床观察

Ligustrazine phosphate used as an add-on therapy for bronchiolitis

目的观察磷酸川芎嗪辅佐治疗毛细支气管炎的临床疗效。方法将100例诊断为毛细支气管炎的患儿随机分为治疗组和对照组各50例,对照组给予常规治疗,治疗组在对照组基础上加磷酸川芎嗪,连用3～7d。结果治疗组临床显效率、总有效率分别为64.00%、96.00%,对照组分别为42.00%、80.00%。两组比较差异均有统计学显著意义(P<0.05);治疗组的喘憋消失时间为(2.21±1.14)d、哮鸣音消失时间为(4.69±1.32)d、咳嗽缓解时间为(5.56±1.62)d及住院时间(7.58±1.82)d,均短于对照组(2.95±1.35)d、(5.64±1.58)d、(6.35±1.84)d和(8.74±2.03)d,P<0.01。结论磷酸川芎嗪辅佐治疗毛细支气管炎临床疗效显著,不良反应少,具有较高的临床应用价值。

Objective To evaluate the efficacy of ligustrazine phosphate used via vein as an add-on therapy for treatment of bronehiolifis. Methods One hundred cases of bronehiolitis were separated randomly into the therapy group and the control group （fifty cases for each）. Both groups received the same routine treatment, but the therapy group used ligustrazine phosphate via vein as an add-on therapy for 3 - 7 days besides routine treatment. Results Therapy group＇s total effective rate was 96. 00% and control group＇s was 80. 00%. There was a statistic difference between two groups（P 〈0. 05） ,and there was also a statistic differenee in curative rate between two groups（64.00% vs 42.00% ,P 〈0. 05）. The therapy group cost shorter time for the release of asthma,wheeze and cough [ （2. 21± 1.14）d,（4. 69 ±1.32） d, （5.56 ±1.62） d] and took fewer days in hospital （7. 58 ±1.82） days than the control group[ （2.95±1.35）d,（5.64±1.58）d,（6.35±1. 84）d,（8.74±2.03） d, P〈0.01].Conelusion Ligus- trazine phosphate used via vein as an add-on therapy for bronchiolitis has remarkable and expected effects with little side one ,it is worthy of application.