不同剂量阿托伐他汀对颈动脉粥样斑块的影响

Clinical Effect of Two Different Doses of Atorvastatin on Carotid Atherosclerosis Plaques

目的研究不同剂量阿托伐他汀对颈动脉粥样硬化斑块的影响。方法应用彩色多谱勒超声检出颈动脉粥样硬化斑块形成者98例,随机分为A组(常规治疗对照组)、B组(常规治疗加口服阿托伐他汀10mg)和C组(常规治疗加口服阿托伐他汀20mg),治疗6月后比较治疗前后血脂、颈动脉内膜中层厚度(IMT)及斑块大小的变化。结果A组、B组、C组治疗后IMT分别为(1.08±0.16)mm,(0.96±0.11)mm,(0.92±0.09)mm,C组治疗后IMT较A组、B组及治疗前有明显差异(P<0.05)。C组总胆固醇(TC)和低密度脂蛋白胆固醇(LDL-C)治疗后较A组降低。斑块大小治疗前后以及和对照组比较差异无显著性。结论阿托伐他汀能延缓颈动脉粥样硬化斑块的进展,长期每天服用阿托伐他汀20mg比10mg疗效明显。

Objective To investigate the effect of two different doses of atorvastatin on carotid atherosclerosis plaques. Methods Carotid atherosclerosis plaques were assessed by color Doppler ultrasound, 98 patients with carotid atherosclerosis plaques were selected, and they were divided into three groups, 10 mg group（atorvastatin l0 mg,p, o., q. n. ）, 20 mg group（atorvastatin 20 mg, p. o., q. n. ） and control group （without atorvastatin）. The effects of atorvastatin on the patients＇ lipid parameters including total cholesterol（HDL-C） and triglyceride（TG） were observed. Results After 6-month treatment, the intimamedia thickness（IMT） of bilateral carotid arteries and plaque morphology of three groups were （1.08 ±0. 16）mm, （0. 96 ±0. 11）mm and （0. 92 ±0. 09） mm, respectively. The IMT in 20 mg group in 6 months was thinner than that in 10 mg group and control group, there was significant difference（P〈0.05）. After treatment with atorvastatin, the size of plaque was not statistically significant among three groups. Conclusion Atorvastatin is effective to prevent the progression of plaques. Longterm administration of atorvastatin 20 mg per day is good choice.