不同剂量木糖醇添加剂对抗生素骨水泥药物释放的影响

Influence of Different Doses of Xylitol Additive on the Release of the Antibiotic Bone Cement

目的:探讨不同剂量木糖醇添加剂对抗生素骨水泥药物释放的影响,以确定最佳剂量指导临床用药。方法:不同剂量(0 g,7 g,14 g,21 g,28 g)的小颗粒木糖醇添加剂(210μm^250μm)分别与2 g万古霉素和40 g骨水泥聚合后进行洗提实验。结果:不同剂量组药物释放的模式与无添加剂组一致,即前24 h大量释放和随后的持续低浓度释放。21 g小颗粒木糖醇添加剂既可以使药物释放量大大增加(P<0.05),也使高于最低抑菌浓度持续时间最长≥20 d。结论:添加剂在21 g可能是最适剂量。

Objective： To evaluate the influence on the release of antibiotic bone cement of different doses of xylitol additive to determine the optimal dose to guide the clinical administration. Methods： Different doses （0 g,7 g, 14 g, 21 g,28 g） of small particle xylitol additive （210 μm -250 μm）were respectively polymerized with 2 g vancomycin and 40 g bone cement to carry out elution experiment. Results： The drug-release patterns of the different doses of groups were concordant with the non-additive group, namely a great of release before the first 24 hours and the release of subsequent sustained lower concentration. Small particle xylitol additive of 21 g may not only make the drug released amount increased （P 〈0.05） but make the sustained time of higher minimum antibacterial concentration longest （≥120 d）. Conclusion： The additive in 21g may be the optimal dose.