甲状腺功能减退症合并阻塞性睡眠呼吸暂停低通气综合征8例临床分析

Clinical analysis of eight cases of hypothyroidism accompanied by obstructive sleep apnea-hypopnea syndrome

目的加深对甲状腺功能减退症与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)之间关系的认识,以提高诊断和治疗水平。方法回顾性分析8例甲状腺功能减退症合并OSAHS患者的临床资料。全部患者均经甲状腺功能检查和多导睡眠仪监测而明确诊断。治疗上主要采用甲状腺素替代疗法,部分患者辅以持续正压通气(CPAP)治疗或手术治疗。结果采用甲状腺素替代疗法可缓解症状(如肥胖、嗜睡、水肿、便秘、声音嘶哑等)和改善夜间睡眠呼吸暂停。结论采用甲状腺素替代治疗甲状腺功能减退症合并OSAHS可取得一定的效果,但常需配合CPAP或手术治疗。

Objective To explore the relationship between obstructive sleep apnea- hypopnea syndrome （OSAHS） and hypothyroidism, and to discuss the proficiency of diagnosis and treatment. Method The clinical data of 8 cases of OSAHS with hypothyroidism were reviewed. ,The patients were diagnosed by thyroid hormone determinations and polysomnography and were treated with thyroid hormone replacement therapy. Part of the cases underwent adjuvant continuous positive airway pressure （CPAP） or surgical treatment at the same time. Result Thyroid hormone replacement therapy was effective in relieving symptoms （obesity, narcolepsy, edema, constipation, dysphonia, etc. ） and improving nocturnal sleep apnea. Conclusion Thyroid hormone replacement therapy for typothyroidism with OSAHS has satisfactory results, whereas CPAP or surgical treatment are required as adjuvant therapy in some cases.