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氯沙坦对缺血性心肌病患者纤溶系统的影响

The effects which acted on fibrinogenolytic system of ischemia myocardial disease patients by telmisartan
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摘要 目的探讨氯沙坦对缺血性心肌病患者纤溶系统的影响及作用机制。方法选取60例患者晨起采集肘静脉血2ml,以0.129mmol/L枸橼酸钠1∶9抗凝3000r/min离心10min收取上清液-70℃保存待测组织纤溶酶原激活剂(t-pA)及其抑制物PAI-1活性,D-二聚体含量采用酶联免疫双抗体夹心法。结果氯沙坦治疗后血浆PAI-1活性,D-二聚体含量明显降低(P<0.01)。结论氯沙坦可改善缺血性心肌病患者的纤溶指标,无禁忌证的患者应常规应用。 Objective To explore the affection and function mechanism of ARB to fibrinogenolytic system of ischemia myocardial disease patients.Methods 60 cases of chosen patients were collected 2ml elbow vein blood which were 1 to 9 anticoagulated with 0.129mol/L sodium citrate,then the upper serum was collected and conserved in-70℃ after 3000rpm centrifugalizing for ten minutes.t-PA,PAI-1 activity,D-diner contents were determined by ELISA way.Results the plasma PAI-1 activity,D-diner were obviously reduced（P〈0.01）and t-PA activity obviously rising（P〈0.01）after ARB treatment.Conclusion ARB can improve fibrinogenolytic index of ischemia myocardial disease patients,it can be applied routinely for no contraindication patients.
作者 郑琼 姚岳红
机构地区 江门市第二人民医院心内科 四川省妇幼保健院
出处 《四川医学》 CAS 2010年第3期365-366,共2页 Sichuan Medical Journal
关键词 缺血性心肌病 t-pA及其抑制物 PAI-1活性 D-二聚体含量 氯沙坦 ischemia myocardial disease t-PA PAI-1 D-diner contents losartan
分类号 R542.2 [医药卫生—心血管疾病]
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参考文献8

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四川医学
2010年 第3期

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