摘要
Fractalkine足趋化因子家族的新成员，以膜结合形式和可溶性形式存在，兼有黏附分子和趋化因子的活性。CX3CR1足其特异性受体，二者在神经系统的诸多疾病中均有表达。目前，fractalkine及其受体CX3CR1的基因多态性与脑血管病的研究，主要涉及脑血管病的危险因素、脑缺血再灌注及骨髓干细胞移植等方面，有望成为临床治疗的新靶点。
Fractalkine is a new member of chemokine family, which exists in membranebound form and soluble form. It has both adhesion molecular and chemokine activities. CX3 CR1 is its specific receptor. Both of them were expressed in many diseases of the nervous system. At present, fractalkine and its receptor CX3 CR1 polymorphism and the research of cerebrovascular diseases mainly involve in the risk factors for cerebrovascular diseases, cerebral ischemiareperfusion and bone marrow stem cell transplantion, which are expected to become a new target for clinical treatment.
出处
《国际脑血管病杂志》
北大核心
2010年第2期142-145,共4页
International Journal of Cerebrovascular Diseases
