胰岛素抵抗与阿尔茨海默病关系研究进展

The relationship between insulin resistance and Alzheimer's disease research progress

糖尿病与认知功能损害都是中老年人易患疾病。糖尿病是脑卒中的已知危险因素,会导致血管性痴呆,但与阿尔茨海默病之间的相关性仍无定论,大多数研究认为两者呈正相关,部分研究认为两者无关。阿尔茨海默病有明显的脑内胰岛素抵抗现象,胰岛素及其增敏剂类药物不仅能够提高胰岛素受体的敏感度,还能够减轻炎症反应、促进Aβ淀粉样蛋白的释放和清除,有益于记忆功能的改善。

Both diabetes meUitus and cognitive impairment are frequent disorders in elderly people, Diabetes mellitus as a risk factor for stroke can cause vascular dementia. However,it is still no final conclusion whether it can cause Alzheimer＇ s disease or not, Most researches indicate that two diseases are positive correlation, but a few suggest no correlation between them. The brain of Alzheimer＇s disease has obvious phenomenon of insulin resistance,insulin and insulin sensitizers drugs can not only improve the sensitivity of insulin receptors,but also reduce the inflammatory response, promoting Aβ-amyloid release and clearance, benefiting of improvement in memory function.