摘要
肥胖不仅是糖尿病、冠心病、高血压的高危因素,还可能导致肾脏损害。糖尿病肾病是糖尿病常见的慢性微血管并发症,是造成终末期肾病的主要原因。已有研究证明肥胖的2型糖尿病患者具有明显的多种代谢异常,能促进糖尿病肾病的发生发展。本文就肥胖导致糖尿病患者肾脏的损伤机制及糖尿病肾病的相关药物治疗做一综述。
Obesity is not only the high risk factor of diabetes mellitus, coronary heart disease and hypertension,but also a cause of renal damage. Diabetic nephropathy is one of the most frequent chronic microvascular complications of diabetes mellitus, and one of the leading causes of end-stage kidney failure. It is documented that the obese patients with type 2 diabetes may have obviously multiple metabolic abnormalities and are more prone to develop diabetic nephropathy. This article summarized the pathogenetic mechanisms of kidney injury in diabetic obese patients and provided some ideas in the medical therapy of diabetic nephropathy.
出处
《中国实用内科杂志》
CAS
CSCD
北大核心
2010年第3期270-272,共3页
Chinese Journal of Practical Internal Medicine
关键词
肥胖
糖尿病
糖尿病肾病
obesity
diabetes mellitus
diabetic nephropathy
