儿童急性淋巴细胞白血病微小残留病的检测及其临床意义

Detection of minimal residual disease in childhood acute lymphoblastic leukemia： methodologic advances and clinical significance

尽管目前儿童急性淋巴细胞白血病诱导缓解率已明显提高，但仍有部分患儿完全缓解后复发。微小残留病（MRD）的存在是导致其复发的主要原因。研究表明MRD的有无及其高低不但反映了个体对治疗的反应情况，还能用于临床危险度分型及移植后复发风险的评估。该文对MRD的检测方法及临床意义作一综述。

Mttltiagent chemotherapy has significantly improved survival for childhood ALL. However, the relapse rate with current therapies remains at 20% to 30%. Numerous studies have proved that the minimal residual disease（MRD） is associated with relapse rate. The major methods for the detection of MRD include polymerase chain reaction（PCR） and flow cytometry （FCM）. The measurement of MRD in childhood acute lymphoblastic leukemia offers the promise of individualized, risk-stratified treatment and the prediction for post-transplant outcome.