斑马鱼应用于肾脏研究的进展

Progress of zebrafish applied to kidney research

目前斑马鱼作为一种新的模式动物越来越受科学家们重视，因其与哺乳动物肾脏的发育及疾病的发生、发展存在很多相似之处，涉及的许多基因具有高度保守性，且结构简单、易于操作和观察，已被广泛应用于肾脏领域的研究。该文对斑马鱼作为一种模式生物在肾脏发育和肾脏疾病中的应用进行综述。

As a kind of new model organisms, zebrahsh attracts more and more scientists attenlaon. Because the nephrogenesis and much of kidney disease in zebrafish are similar to those in mammalian, many genes in both kidneys are conserved,and zebrafish has the more simple pronephron, which is convenient to operation and observation. The fish pronephron has been generally applied to study the development and disease of mammalian kidney. This review will focus on recent progress in applying the zehrafish pronephrons to issues of human health and development.