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PAX2在肾脏中表达及其意义 被引量：3

PAX2 expression and its significance in kidneys
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摘要 PAX2转录因子是肾脏发育的重要调控因子，可在前肾、中肾和后肾发育的全过程中表达，参与胚胎肾脏各个发育阶段的调控，在成熟肾单位表达消失。近来发现，PAX2在病理肾中出现再表达，其基因突变和重新表达与肾脏先天及后天性疾病紧密相关。该文从PAX2的正常表达、基因突变与异常表达在肾脏疾病中的作用和意义方面展开综述。 PAX2 gene encodes a nuclear transcription factor and plays a pivotal role for embryonic kidney development. It is expressed during the entire developmental process of pmnephron, mesonephron and metanephron, involving in the regulation of embryonic kidney development at various fetal stages, but its expression disappeared in mature nephrous. Recently, it was found that PAX2 was re-expressed in nephropathy. Gene mutation and re-expression of PAX：2 are closely related with congenital and acquired renal diseases. This paper reviews the role and significance of PAX2 expression in kidney disease from the aspects of normal expression, gene mutation and abnormal expression.
作者 李丽 赵冬梅(综述) 吴玉斌(审校)
机构地区 中国医科大学附属盛京医院小儿肾内科 佳木斯大学附属第一医院儿科
出处 《国际儿科学杂志》 2010年第2期186-189,共4页 International Journal of Pediatrics
关键词 PAX2 肾脏 肾脏疾病 PAX2 Kidney Kidney disease
分类号 R692 [医药卫生—泌尿科学]
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参考文献25

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二级参考文献13

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共引文献5

同被引文献48

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国际儿科学杂志
2010年 第2期

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