利奈唑胺致血小板减少3例

Thrombocytopenia induced by linezolid in three patients

3例男性患者,年龄46～91岁,给予利奈唑胺600mg,2次/d静脉滴注治疗感染。给药前血小板计数正常,治疗3～17d后均出现血小板减少。血小板计数分别为95×109/L、74×109/L、86×109/L。停用利奈唑胺,改用亚胺培南-西司他丁钠、万古霉素、美洛培南,其他治疗不变,2～9d后血小板计数恢复正常。

Three male patients,aged 46~91 years,received respectively an IV infusion of linezolid 600 mg twice daily for infections.Their platelet counts were normal before linezolid administration.All of them developed thrombocytopenia after 3~17 days of therapy.Platelet counts were 95×109/L,74×109/L,and 86×109/L,respectively.Linezolid was stopped and switched to imipenem-cilastatin sodium,vancomycin,and meropenem;and other treatments were unchanged.The level of platelet returned to within normal range.