摘要
两例患者因肺结核咯血静脉滴注垂体后叶素出现渗透性脱髓鞘综合征。例1为45岁男性患者,首日静脉滴注垂体后叶素10U,第2、3、4天为24～36U/d。第5天停药。因再现咯血,给予垂体后叶素24U/d,共2d。之后,患者出现烦躁不安、言语混乱,四肢不自主运动、实验室检查示血钠110mmol/L,补钠治疗2d后血钠升为134mmol/L。头颅MRI示双侧尾状核、豆状核对称性长T1、T2信号改变。经对症治疗后,患者症状有所好转。
Two patients developed osmotic demyelination syndrome after receiving an IV infusion of pituitrin for hemoptysis secondary to pulmonary tuberculosis.Patient 1,a 45-year-old man,received an IV infusion of pituitrin 10U on day 1,followed by 24~36U/d on days 2,3,and 4.On day 5,pituitrin was discontinued.Pituitrin 24U/d was readministered for 2 days due to recurrence of hemoptysis.Subsequently,the patient developed agitation,paraphasia,and involuntary movement of his extremities.Laboratory testing revealed a blood sodium level of 110 mmol/L.After receiving a sodium supplement for 2 days,his blood sodium level increased to 134 mmol/L.A cranial MRT revealed symmetrical signal abnormities on long T1 and long T2 in his bilateral caudate nuclei and lenticular nuclei.Symptomatic treatments were given and the patients＇symptoms improved somewhat.
出处
《药物不良反应杂志》
2010年第1期56-58,共3页
Adverse Drug Reactions Journal
