复方甘草酸苷注射液引起假性醛固酮增多症

Pseudohyperaldosteronism caused by compound glycyrrhizin injection

1例38岁女性患者,因服用酮康唑导致药物性肝损害入院。入院后给予复方甘草酸苷注射液100ml(含甘草酸苷200mg)加入5%葡萄糖注射液250ml静脉滴注,共2周。随后,患者出现全身水肿,双下肢明显,血压波动在136～140/90～100mmHg,血钾2.56mmol/L。停用该药,给予螺内酯片及氯化钾控释片治疗,7d后症状好转。入院26d痊愈出院,随访2周无不适。

A 38-year-old woman was hospitalized for drug-induced liver damage due to ketoconazole.After admission,the patient received an IV infusion of compound glycyrrhizin injection 100 ml（containing glycyrrhizin 200 mg） in 5% glucose 250 ml for two weeks.Subsequently,she developed generalized edema which was marked in her both lower extremities.Her blood pressure was within 136~140/90~100 mm Hg and the level of serum potassium was 2.56 mmol/L.The drug was discontinued,spironolactone tablets and controlled-release potassium chloride tablets were given.Seven days later,her symptoms improved.She was discharged after 26 days of hospitalization and had no discomfort at 2-week follow up.