常用羧酸类及其衍生物药用辅料的拉曼光谱鉴别

Qualitative analysis of carboxylic acids and commonly used derivatives as pharmaceutical excipients by Raman spectra

目的:建立羧酸类及其衍生物药用辅料的拉曼光谱定性鉴别方法。方法:收集常用羧酸类及其衍生物药用辅料的拉曼光谱,对拉曼光谱峰进行指认,分析比较了结构和光谱差异之间的关系。结果:拉曼光谱可以给出关于化合物结构的指纹信息,并可和红外光谱相互补充佐证。结论:建立的方法快速、简便、专属性强,可用于羧酸类及其衍生物药用辅料的鉴别。

Objective：To develop a Raman spectroscopy method for the qualitative analysis of the carboxylic acids and derivatives commonly used as pharmaceutical excipients.Methods： Raman spectra of the carboxyl and related excipients were collected, the attribution of the observed frequencies in the spectra and their association with specific modes of vibration were assigned.According to the structure, the similarities and differences among them were studied by comparing.Results：Raman spectra, similar to and complementary to IR spectra, can give the finger prints information about the corresponding structure.Conclusion：The method is rapid, simple and specific for the qualitative analysis of pharmaceutical excipients.