MDR1基因多态性对妇科患者芬太尼静脉镇痛药效学的影响

Genetic Polymorphisms in the MDR1 Gene and Effects on Analgesia Pharmacodynamic of Fentanyl

目的观察MDR1C3435T多态性对妇科患者芬太尼静脉镇痛效应的影响。方法196例全麻下行妇科择期手术的患者,手术结束患者清醒后行芬太尼患者自控静脉镇痛(PCIA)。记录患者自控静脉镇痛24h内芬太尼用量。采用聚合酶链反应-限制性片断长度多态性(PCR-RFLP)技术检测MDR1C3435T多态性。结果196例患者中,CC型82例,CT型86例,TT型28例。MDR1C3435T的突变频率为36.2%。术后24h内3组间芬太尼消耗量差异无统计学意义。结论MDR1C3435T多态性不是引起芬太尼药效学差异的遗传因素。

OBJECTIVE To evaluate the impact of MDR1C3435T genetic polymorphism on the analgesic effect of fentanyl.METHODS One hundred and ninety-six patients scheduled for elective Gynecologic surgery undergoing general anesthesia were enrolled in this study.Fentanyl PCIA was then performed after the patients came to consciousness.The amount of fentanyl used within 24 h during PCIA was recorded.The polymorphic sites of MDR1C3435T allele were analyzed by polymerase chain reaction-restiction fragment length polymorphism（PCR-RFLP）.RESULTS 82 wildtype homozygotes（CC）,86 heterozygotes（CT）,and 28 mutant homozygotes（TT）were determined for MDR1C3435T.Within 24 h after operation among the three groups,no significant difference in fentanyl consumption were found.CONCLUSION MDR1C3435T genetic polymorphism has no effects on the individual variation of patient＇s response to analgesia of fentanyl.