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固体脂质纳米粒克服肿瘤多药耐药的研究进展 被引量:4

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摘要 目的介绍近年来固体脂质纳米粒克服多药耐药的研究进展。方法查阅相关文献,就固体脂质纳米粒的相关特点、水溶性细胞毒药物的固体脂质纳米粒的制备、固体脂质纳米粒克服多药耐药以及其可能的机制进行归纳、总结。结果与结论固体脂质纳米粒是克服多药耐药的一种新策略。借鉴脂质体研究的经验,温度敏感、pH敏感、PEG化、与肿瘤靶向抗体联合应用以及与逆转剂联合应用等手段有望成为固体脂质纳米粒克服多药耐药的新思路。
出处 《中国药学杂志》 CAS CSCD 北大核心 2010年第6期401-403,共3页 Chinese Pharmaceutical Journal
基金 国家自然科学基金资助项目(30572270) 浙江省自然科学基金资助项目(Y207259)
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