摘要
PepT2(peptide transporter 2)是一种高亲和力、低容量的转运载体.它在人体中分布广泛,不仅能转运二、三肽,也可以识别和转运许多仿肽类药物,如β-内酰胺抗生素、血管紧张素转换酶抑制剂、贝他定等.研究表明,PepT2的转运机制不同于氨基酸的吸收机制,其底物的仿肽结构特征影响其转运速率.本文综述了PepT2与药物相互作用的研究以及PepT2转运药物底物结构特征的研究进展.
PepT2（peptide transporter 2）is a high-affinity and low-capacity transporter that is widely distributed in the body to transport di-peptides,tri-peptides,as well as various peptidyl drugs,such as β-lactam antibiotics,angiotensin-converting enzyme inhibitors and bestatin.It was demonstrated that mechanism of PepT2-mediated transportation was different from the absorption of amino acids.The transport rates of the substrates were affected by their structural characteristics.This reviews focuses on the recent progress about the interactions between PepT2 and the characteristics of its delivered drugs.The future prospects for PepT2 and drug design are also discussed.
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2010年第1期1-8,共8页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金(No.20572016
20772023)
河南省教育厅科技计划(No.2006KYCX017)资助项目~~
关键词
寡肽转运蛋白
PepT2
药物转运
相互作用
peptide transporter
peptide transporter 2
drug delivery
interaction in research
