EB病毒潜伏膜蛋白-1和环氧合酶-2及血管内皮生长因子C在鼻咽癌中的表达及其关系

Expression and relationship of EBV LMP1,COX-2 and VEGF-C in nasopharyngeal carcinoma

目的:探讨血管内皮生长因子C(VEGF-C)、环氧合酶-2(COX-2)及EB病毒潜伏膜蛋白-1(LMP1)在鼻咽癌中的表达及其关系。方法:采用免疫组织化学法检测57例鼻咽癌组织中LMP1、COX-2及VEGF-C在鼻咽癌组织中的表达。结果:鼻咽癌组织中LMP1、COX-2及VEGF-C表达率分别为49.1%(28/57)、75.4%(43/57)和59.6%(34/57);经Spearman相关分析,它们之间呈相互正相关关系(均P<0.05)。结论:鼻咽癌中LMP1及COX-2可能直接上调VEGF-C表达,或者LMP1通过促进COX-2表达上调VEGF-C表达,从而对肿瘤的淋巴转移及发生发展起到促进作用。

Objective：To evaluate the expression of vascular endothelial growth factor C（VEGF-C）,Epstein-Barr virus（EBV） latent membrane protein 1（LMP1）,cyclooxygenase-2 （COX-2） in nasopharyngeal carcinoma（NPC）.Method：LMP1,COX-2 and VEGF-C were detects by immunohistochemical staining for 57 case NPC tissue.Result：The positives rates of LMP1,COX-2 and VEGF-C detected by immunohistochemical staining were 49.1%（28/57）,75.4%（43/57）and 59.6%（34/57）,respectively. The expression of LMP1,COX-2 and VEGF-C were correlated to each1 other in NPC（P〈0.05）.Conclusion：LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression,may contribute to lymph metastasis and develop NPC.