CD137L在喉癌中的表达及其临床病理学意义

Clinicopathological significance of CD137L expression in laryngeal carcinoma

目的:检测CD137L在喉癌中的表达,探讨其在喉癌发生和发展中的作用。方法:应用免疫组织化学染色法检测50例喉癌肿瘤组织和9例癌旁正常喉黏膜CD137L的表达。结果:CD137L在50例喉癌中阳性表达率为100%,而在9例癌旁正常喉黏膜组织中CD137L蛋白表达为阴性,与癌旁正常喉黏膜组织比较,喉癌CD137L阳性表达率明显增高,差异有统计学意义(P<0.01)。CD137L表达与患者年龄、性别和肿瘤生长部位无相关性,而与病理学分级、肿瘤T分期和有无淋巴结转移相关。结论:CD137L在喉癌组织的表达在喉癌发展过程中发挥重要作用。

Objective：To study the expression of CD137L in laryngeal carcinoma,and to analyze its clinicopathological significance.Method：The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining.Result：The positive CD137L staining were found in all 50 cases of laryngeal carcinomas （100%）,while its staining were negative in normal laryngeal mucous. There was significant difference between two groups（P〈0.01）. The positive ratio of CD137L staining had no relationship with the factors such as age,sex and tumor site,while it had significant correlation with the pathological stage,T stage and lymph node metastasis.Conclusion：The expression of CD137L might play an important role in the development of laryngeal carcinomas.