IAP家族分子与肿瘤靶向治疗

IAP family and IAP-targeted cancer therapy

凋亡抑制因子(inhibitor of apoptosis proteins,IAPs)是一类高度保守的内源性抗细胞凋亡因子家族,主要通过抑制Caspase活性和参与调节核因子NF-κB的作用而抑制细胞凋亡。细胞抗凋亡机制在肿瘤发生、发展以及肿瘤耐药性形成中发挥重要作用。肿瘤细胞高表达IAPs是导致肿瘤细胞抵抗凋亡的关键。细胞凋亡调控异常与肿瘤细胞耐药密切相关,增强肿瘤细胞对化疗药物的敏感性成为近年来肿瘤治疗的重要策略之一。该文综述了IAP家族蛋白的结构、生物学特性及其作为肿瘤治疗靶点的研究进展。

The inhibitor of apoptosis proteins（IAPs） are known as a group of highly conserved endogenous proteins that regulate the activity of caspases and NF-kB survival pathways.The mechanism of resistant apoptosis has played a crucial role in the tumorigenesis,tumor progress and drug resistance.Overexpression of IAPs has been shown to confer protection against a number of apoptosis in a variety of stress and is believed to have important consequences with respect to human cancer.Deregulation of apoptosis is associated to tumor resistance to chemo therapeutic agents.Enhanced chemosensitivity of tumor cells is one of importanttherapeutic strategies for cancer therapy.This review will focus on biological characteristics and the structure of IAP proteins,and IAP-targeted therapies for cancer treatment.