固齿膏对牙周炎组织中PGs的影响

Effects or Cu Chi paste on PGE2 in periodontitis tissues of guinea pigs

目的研究固齿合对牙龈和牙槽骨中PGE2的抑制作用，探讨固齿膏治疗牙周炎的机理。方法用丝线缝扎和给豚鼠喂养高糖形成牙周炎，分别给豚鼠喂固齿育和吲哚美辛，放射免疫测定法分析牙龈和牙槽骨中PGE2含量。结果牙周炎组的牙龈指数和牙周袋深度增加，牙槽骨吸收明显．牙龈和牙槽骨中的PGE2明显升高；固齿膏组牙龈指数和牙周袋深度明显低于牙周炎组，牙槽骨吸收减轻，牙龈和牙槽骨中PGE2含量明显降低，牙槽骨中的PGE2含量与吲哚美辛组有显著性差异，而牙龈组织中的PGE2含量与吲哚美辛组无显著性差异。结论固齿膏对实验性牙周炎的形成有抑制作用．能明显降低牙龈和牙槽骨中的PGE2含量。

Objective Study the effects of Gu Chi paste on PGE2 in gingiva and alveolar bone and its mechanism to treating periodontitis. Methods Periodontitis were formed with silk thread suture and high sugar diet .fed guinea pigs on Gu Chi paste and indomethacin. The prostaglandin E2 (PGE2) in gingiva and alveolar bone were measured with radioimmunoassay (RIA). Results The Gingival index (GI) and Pocket Deep (PD) of group Periodontitis (PE) were bigger than group Normal (N ). the alveolar bone absorbed more severe,the PGE2 level in gingiva and alveolar bone in PE was higher than that in N. The GI and PD of group Gu Chi paste (Gu) were lower than that of PE, its alveolar bone absorbed more slight. There were more significant difference of PGEZ in gingiva and alveolar bone between Gu and PE. There were more significant difference of PGE2 in alveolar bone between Gu and group indomethacin(IND). The PGE2 level of Gu in gingiva were similar as that of IND. Conclusion Gu Chi paste can inhibite the formation of experimental periodontitis and the contents of PGE2 in gingiva and alveolar bone,and the effect on PGE, in alveolar was more severe. The mechanism of Gu Chi paste to periodontitis has inhibitory effects on PGE2 in gingiva and alveolar bone. [