雌激素受体在口腔粘膜癌前病变中的表达及意义

The content of estradiol receptors in oral mucosa precancerous lesions and its effect

目的阐明雌激素受体（ER）在口腔粘膜癌变过程中的表达状况及其对临床诊断、治疗的意义。方法采用链霉素抗生物素蛋白一过氧化物物酶（SP）免疫组化法，检测了口腔鳞状细胞癌（SCC）、口腔白斑（1．K）、口腔扁平苔藓（I．P）、正常口腔粘膜（NM）中的ER表达状况。结果NM中42．86％ER阳性，成灶状分布于棘细胞层内，胞浆染色均匀。IP、IK、SCC中ER阳性率分别为71．43％、60．0％、68．42％，成片位于棘层胞浆中，胞浆染色不均匀。ER表达与患者性别、病理类型无关。结论提示SCC、LK、LP中ER存在是确实的，口腔粘膜肿瘤可能是激素依赖肿瘤。但ER不宜作为监测癌变潜能的指标。

Objective In order to clarify the content of estrogen receptors (ER) in oral mucosa precancerous lesions and its effect on dignosis and treatment. Methods ER was measured by SP Inethod in 19 oral squamous cell carcinoma (SCC), 20 oral leukoplakia(I-K), ZI oral lichen planus (1.P) and 7 normal mucosa (NM). Results 42. 86 %, 71. 43 %, 60. 00%,68. 42% were ER positive in NM, I-P, I-K, SCC respectively. The positive cells located inspinous layer. ER contents were no significance different in these four diseases. There was norelationship between ER content and pathologic staging. Conclusion it showed that ERexisted in SCC, I-K, l.p and NM, but it could not implicate for the carcinogenesis. oralmucousal tumor is perhaps hormone depended.[