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磺胺二甲嘧啶生理药动学模型种间类推的应用 被引量：2

The Interspecies Extrapolation of Sulfamethazine Physiologically Based Pharmacokinetic Model
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摘要 本研究应用磺胺二甲嘧啶在猪的生理药动学模型来预测其在绵羊体内的动力学过程。利用文献中已经建立的猪的生理模型,采用动物种间类推原理,将模型外推至绵羊,模拟磺胺二甲嘧啶在绵羊体内的血药和组织浓度,并估算可食性组织残留休药期。结果模拟休药期和文献休药期基本趋于一致,表明生理药动学模型种间类推是可行的。 The objective of this paper was to predict kinetic process of Sulfamethazine in sheep on the basis of the physiologically based pharmacokinetic model of Sulfamethazine in pig.The PBPK model in pig was extrapolated to sheep based on the interspecies scaling theory,to simulate the plasma and tissues concentration of Sulfamethazine and estimate residue withdrawal times in edible tissues in sheep.The results showed that the simulated withdrawal times was according to the reported withdrawal times.The interspecies extrapolation of PBPK model was feasible.
作者 罗显阳 远立国
机构地区 华南农业大学兽医学院
出处 《中国畜牧兽医》 CAS 北大核心 2010年第3期194-197,共4页 China Animal Husbandry & Veterinary Medicine
关键词 磺胺二甲嘧啶 生理药动学模型 绵羊 Sulfamethazine physiologically based pharmacokinetic model sheep
分类号 S859.7 [农业科学—临床兽医学]
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参考文献14

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同被引文献36

  • 1姚美村,姜晓飞,陆亚松,乔延江.生理药动学模型及其在中药研究中的应用[J].世界科学技术-中医药现代化,2007,9(3):55-59. 被引量：7
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  • 9杨波,黄玲利,袁宗辉,等.生理药动学模型的软件研究概况[C].第十一届全国数学药理学学术会议,2007.
  • 10蔡劳芹.环丙沙星在大鼠的生理药物动力学模型及其种属间外推[D].广州:华南农业大学,2007.

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二级引证文献4

中国畜牧兽医
2010年 第3期

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