心肌组织和血浆IGF—Ⅰ的相关性

A study on the reletionship of the level of IGF-I between heart tissue and blood plasma

本研究采用放射免疫分析法测定自发性高血压大鼠(SHR)和正常血压的Witar-Kyoto大鼠(WKY)血浆和心肌组织中的IGF-Ⅰ水平,以心脏湿重(HW)和心脏湿重/体重(HW/BW)来判定心肌肥厚.结果显示:SHR的HW较WKY有显著升高(P<0.05),HW/BM则较WKY有高度显著升高(P<0.01).两组大鼠心肌组织中IGF-Ⅰ与血浆中的IGF-Ⅰ显示正相关(WKY:r=0.8485 P<0.05;SHR:r=0.9529(P<0.005).试验结果提示不论心脏生理和病理情况下,心脏合成和分泌的IGF-Ⅰ对循环中的IGF-Ⅰ水平均有影响,而在心肌肥厚,心肌组织中的IGF-Ⅰ病理水平增高时,影响更为明显.

In this study the level of insulin - like growth factor I (IGF - I )in heart tissue and plasm of spontaneously hypertensive rats (SHR) and Wistar - Kyoto rats(WKY) was measured with radioimmunoassay .The heart hypertrophy was de-terminded by the heart weight(HW)and heart weight/body weight(HW/BW) .It was showed that HW was higher(P < 0.05) in SHR than in WKY.and the HW/BW was much higher (P< 0.0l)in SHR than in WKY.There were a positive correlation between the level of IGF- I in heart and in plasm (WKY: r = 0.8485 P<0.05: SHR: r= 0.9529 P< 0.005) .The above results suggest that the level of IGF - I in blood is affected by the IGF - I produced in heart regardless of whether the heart is physiologic or pathologic.There is a positive correlation between them.