动脉灌注化疗并栓塞治疗中晚期恶性肿瘤935例临床疗效及并发症分析

Analysis of Clinical Therapeutic Effectiveness and Complication of Combined Therapy by Arterial Perfusion and Embolic Therapy in the 935 Cases with Middle and Late Stage Malignant Tumours.

目的:为总结动脉灌注化疗合并栓塞术治疗各种中晚期恶性肿瘤的临床疗效以及并发症发生的原因。材料与方法:采用回顾性临床总结过去6年中935例各种中晚期肿瘤.共进行动脉插管化疔药物灌注2715例次,肿瘤供血动脉栓塞675例次,所用化疗药物一般2～3联.所用栓塞剂为40%碘化油5～20ml 以及明胶海绵碎屑。结果:935例病人CR113例,PR201例,MR288例,SD241例,PD92例,总有效率(CR+PR+MR)为63.2%。栓塞后综合征发生率为6.6%。结论:经皮穿刺肿瘤供血动脉插管化疗药物灌注及栓塞术对中晚期恶性肿瘤的疗效肯定。

Aim:To summarize the clinical therapeutic effectiveness,the rate and the cause of complication in the various meddle and late stage malignant tumours,using combined treatment of arterial perfusion chemo therapy and embolization. Materials anti Methods:Through retrospective clinic summary in the past 6 years,935 eases of middle and late stage malignant tumor were given 2715 times of arterial perfusion chemo- therapy,675 times embolic therapy.Combined 2～3 kinds chemothcrapetie drugs were given. The embolizers were consisted of 40% iodized oil 5～20ml and fragments of gelfoam.Resuhs:In the 935 cases,there were CR 113,PR 201,MR 288,SD 241 and PD 92.The effective rate was 63.2%(CR+PR+MR).In this group,876 cases survived for 3 months;668 cases for 3～6 months;476 cases for 6～12 months;238 cases up to 1～2 years;116 cases reaehd more than 2 years.The incidence rate of serious complication was 1.92%(18/935)by calculating the number of the patients;0.66%(18/2715)on the basis of arterial intervention therapy.The incidence rate of embolic syndrome was 6.6%.Conclusion:The therapeutic effectiveness of combined therapy of intraarterial perfusion chemotherpy and embnlic therapy in the middle and late stage malignant tumours is significantly higher than intravenous chemotherapy.Part of got chances to be operated again.Some proportions of complication and side raaction may occur so that emergency treatment should be ready at hand.