我院128例药品不良反应报告分析

Analysis of 128 adverse drug reaction reports in our hospital

目的了解我院药品不良反应（ADR）发生情况和特点。方法分别从患者性别、年龄、引起ADR的药品、给药途径以及临床具体表现等方面对我院2005~2007年上报的128例ADR报告进行统计分析。结果128例ADR报告中,老年患者65例,占总例数的50.78%;抗微生物药物引起的ADR最多,占总例数的40.63%（52例）;以静脉滴注方式给药引发的ADR最多,占总例数的75%（96例）;临床表现以皮肤及附件损伤最为常见,占总例数的47.13%（71例）;严重的ADR报告1例,占总例数的0.78%。结论医护药人员应正确理解ADR,加强ADR监测和报告工作,减少或避免ADR的发生。

Objective To investigate the occurrences and features of adverse drug reaction（ADR） in our hospital.Methods 128 ADR reports collected in our hospital in 2005~2007 were analyzed statistically in terms of patients＇ gender difference,age,drug varieties,route of administration and clinical presentation.Results Of the 128 ADR cases,65（50.78%） were inducd by senile patients;Most were induced by antibiotic drugs,which accounted for 40.63%（52 cases）;Most were induced by ivgtt.,which accounted for 75%（96 cases）;The most common clinical manifestations were the damage of skin and adnexa,which accounted for 47.13%（71 cases）;severe ADRS accounted for 0.78%（1 case）.Conclusion Hospital staff should understand correctly ADR and tighten monitoring and report of ADR and try to avoid or minimize ADR cases.