缬沙坦联合银杏叶提取物治疗早期糖尿病肾病的临床研究

The effect of valsartan combined with ginkgo biloba extract in the trealment of early diabetic nephropathy

目的探讨缬沙坦联合银杏叶提取物（EGB）治疗早期糖尿病肾病（DN）的疗效。方法选择早期DN患者112例，按照随机数字表法分为治疗组（58例）和对照组（54例）。两组均给予胰岛素控制血糖及缬沙坦80mg／d；治疗组加用EGB静脉滴注。比较两组患者尿白蛋白排泄率（UAER）、尿β2微球蛋白（13，MG）、血压、空腹血糖（FPG）、血肌酐（SCr）、血尿素氮（BUN）、总胆固醇（TC）、三酰甘油（TG）的变化。结果两组患者治疗前UAER、尿β2-MG、收缩压、舒张压、FPG、BUN、SCr、TG、TC比较差异均无统计学意义（P〉0．05），治疗后各项观察指标均较治疗前明显改善（P〈0．05），且治疗组除收缩压[（130±13）mmHg（1mmHg=0．133kPa）比（129±11）mmHg]外均优于对照组（P〈0．05）。结论缬沙坦联合EGB治疗早期DN疗效显著，能起相互协同增效作用，防止DN的进一步恶化，值得临床推广应用。

Objective To investigate the effect of valsartan combined with ginkgo biloba extract （EGB） in the treatment of early diabetic nephropathy （ DN ）. Methods All of 112 cases of early stage DN patients were randomly divided into treatment group （58 cases） and control group （54 cases）. Two groups were given insulin to control blood glucose and valsartan 80 mg/d. Meanwhile the treatment group was given EGB by intravenous infusion. The changes of urinary protein excretion rate （UAER）, urinary β2-microglobulin （ β2-MG）, blood pressure, fasting glucose, serum creatinine （SCr）, blood urea nitrogen （BUN）, total cholesterol （TC）, triglyceride （TG） were compared. Results There was no significant difference in UAER, β2-MG, systolic blood pressure, diastolic blood pressure, FPG, BUN, SCr, TG and TC before treatment between two groups （P 〉 0.05 ）. After treatment, they were improved in two groups compared with those before treatment （P 〈 0.05 ）. Except for systolic blood pressure [ （ 130 ± 13） mm Hg （ 1 mm Hg = 0.133 kPa） vs（ 129 ± 11 ） mm Hg], the improvement in treatment group was superior to that in control group（P 〈 0,05）. Conclusions Valsartan combined with EGB in treatment of early DN has significant synergies, and they can play roles with each other to prevent further deterioration of DN. This strategy is worthy to be popularized.