偏最小二乘法分光光度同时测定复方扑热息痛片中各组分含量

Simultaneously Determining M ulticomponent of Acetaminophen Compound Tablets by Application of Partial Least Squares Method

本文介绍了偏最小二乘法(PLS)用于多组分分光光度分析的基本原理和算法.研究了复方扑热患痛片中扑热息痛、阿司匹林和咖啡因的PLS测定方法,各组分的平均回收率分别为99.88±0.33％、99.99±0.14％和99.92±1.24％(置信度95％).

The basic principle and computing method of the partial least squares method (PLS) applied to a multicompoent analysis were discussed. The optimum experimental condition of simultaneous UV-spectrophotometric determination of the contents of acetaminophen, aspirin and caffeine in acetaminophen compound tablets and the application of PLS in simultaneous multicomponent determination were studied. The average recovery ratio of the three components are 99. 88±0. 33%, 99. 99± 0. 14% and 99. 92±1. 24% (confidence 95%), respectively. No information has ever been available in the literature for the application of PLS to the pharmaceutical analysis.