长托宁与阿托品治疗急性有机磷中毒的比较研究

Compareison of curative effect of organophosphorus pesticides poisoning with changtuoning or atropine

目的比较观察长托宁与阿托品治疗急性有机磷中毒(AOPP)的疗效及安全性。方法将104例AOPP患者随机分为两组,各52例,观察组以长托宁+氯解磷定治疗,对照组以阿托品+氯解磷定治疗,比较两组的治疗效果。结果观察组治愈率为98.1%,明显高于对照组的86.5%(P(0.05);观察组用药次数、症状消失时间、乙酰胆碱酯酶(AChE)恢复时间、平均住院时间均较对照组明显缩短(P均(0.01);观察组视力模糊、躁动、心动过速、尿潴留等不良反应发生率均比对照组明显减少(P均(0.01)。结论长托宁治疗AOPP具有症状消失快、病程短、AChE活力恢复快、治愈率高、不良反应少、安全可靠等优点,值得在基层医院推广应用。

Objective To compare the efficiency of changtuoning and atropine on cases of acute organophosphorus pesticides poisoning（AOPP）.Methods One hundred and four cases of AOPP were randomly divided into control group（n=52） and observation group（n=52）.The observation groups were treated with changtuoning and pyraloxime chloride,control groups were treated by atropine and pyraloxime chloride.The therapeutic efficiency was compared between the two groups.Results The cure rate of observation group（98.1%） was significantly higher than that of control group（86.5%）（P﹤0.01）;The medication frequency,time of disappearance of symptoms,the recovery time of cholinesterase（ChE）,the average hospitalization days of observation group were significantly shorter than those of control group（all P﹤0.01）;The health behaviors were greatly improved（P﹤0.01）;The incidence rate of adverse reaction in observation group was significantly lower than that of control group（all P﹤0.01）.Conclusion Changtuoning is a safe,highly effective,low toxicity medication treating organophosphorus pesticides poisoning.