序贯疗法与标准三联疗法根除幽门螺杆菌的疗效对比分析——附105例报告

A comparative analysis of 10-day sequential and 7-day triple therapy on eradication of Helicobacter pylori

目的:比较由泮托拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法与标准的7日三联疗法根除幽门螺杆菌(Hp)的疗效及安全性。方法:将105例消化性溃疡或慢性胃炎且Hp阳性成人患者随机分为两组。治疗组(53例)前5日应用泮托拉唑40mg、阿莫西林1000mg,每日2次口服,后5日用泮托拉唑40mg、克拉霉素500mg、替硝唑500mg,每日2次口服。对照组(52例)采用7日泮托拉唑40mg、阿莫西林1000mg、克拉霉素500mg,每日2次口服。停药4周后复查Hp。结果:治疗组Hp根除率为90.6%,对照组为71.2%,两组比较差异有统计学意义(P<0.05);不良反应发生率分别为18.9%和17.3%(P>0.05)。结论:由泮托拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法治疗成人Hp感染的疗效优于标准7日三联疗法。

Objective： To evaluate the effect and safety of 10-day sequential therapy consisted of pantoprazole, clarithromycin, amoxicillin and tinidazole, and 7-day triple therapy in eradicating Helicobacter pylori （Hp） infection. Methods： One hundred and five patients of peptie ulcer and chronic gastritis with Hp-positive were randomly divided into two groups. Ten-day sequential treatment group （53 cases） was pantoprazole 40 rag, amoxicillin 1 000 mg, orally two times a day in first five days, then pantoprazole 40 mg, clarithromycin 500 mg, tinidazole 500 mg, orally two times a day in the second five days. Seven-day triple treatment group （52 cases） was pantoprazole 40 mg, clarithromycin 500 mg and amoxicillin 1 000 mg, orally two times a day for seven days. Results： The eradication rate of 10-day sequential therapy was 90.6%, and the eradication rate of 7-day triple therapy was 71.2%, the result showed a significant difference （P 〈0.05）. The incidence rates of adverse reaction in 10-day sequential therapy group （ 18.9% ） and 7-day triple therapy group （ 17.3% ） were similar （P 〉0. 05）. Conclusion： The 10-day sequential therapy including more effective than 7-day triple therapy on eradication pantoprazole, amoxMllin, clarithromycin and tinidazole was of Hp infection.