乳浆大戟的化学成分(英文)

Diterpenoids from Euphorbia esula

目的:研究乳浆大戟(Euphorbia esula)地上部分的化学成分。方法:利用反复硅胶和凝胶LH-20柱层析进行分离和纯化,通过理化性质和波谱数据分析鉴定化合物结构。结果:分离并鉴定出3个二萜化合物,分别为3,20-dibenzoyloxyingenol(1),3,16-dibenzoyloxy-20-deoxyingenol(2)和3,13,16-tribenzoyloxy-20-deoxyingenol(3)。结论:化合物1为新二萜化合物,3为本植物中首次报道,2和3对Namalwa细胞显示弱的细胞毒活性。

AIM：To study the chemical constituents of the aerial parts of Euphorbia esula.METHODS：Compounds were isolated by repeated column chromatography over silica gel and Sephadex LH-20.Structures were elucidated based on spectral analysis and comparison with literatures.RESULTS：Three ingenane-type diterpenoids were isolated and identified as 16-benzoyloxy-20-deoxyingenol 5-benzoate（1）,ingenol-3,20-dibenzoate（2）and 13,16-dibenzoyloxy-20-deoxyingeno-3-benzoate（3）,respectively. CONCLUSION：Compound 1 is a new ingenane-type diterpenoid diester,and compound 3 was isolated from the plant for the first time.In vitro bioassay data showed that diterpenoids 2 and 3 exhibited weak cytotoxicity against Namalwa cells.