4-(反-4-正丙基环己基)环己基甲酸的研制

Research on 4-(trans-4-propylcyclohexyl) cyclohexylcarboxylic acid

以10%的NaOH水溶液为反应介质,Ni+Ru/C为催化剂,4-(反-4-正丙基环己基)苯甲酸(3HPA)进行加氢反应合成了4-(反-4-正丙基环己基)环己基甲酸(3HHA)。研究了工艺条件对3HHA顺反式的影响,得出最佳合成反应条件:m(Ru/C):m(Ni):m(3HPA)=1:20:100,反应温度180℃,反应压力5MPa。3HPA的转化率接近100%,转型顺/反比例达99:1。

4-（trans-4-n-Propylcyclohexyl） cyclohexylcarboxylic acid（3 H HA） was prepared with 4-（trans- 4-n-propylcyclohexyl） benzoic acid（3HPA） by hydrogenation,using Ni＋Ru/C as catalyst and 10%NaOH aqueous solution as reaction medium.The optimum technological conditions were as follow：m（Ru/C）：m （Ni）：m（3HPA） =1：20：100,reaction temperature 180℃and reaction pressure 5MPa.Under the above optimum conditions,the conversion of 3HPA was close to 100%,and the mass ratio of trans-3HHA to cis- 3HHA was 99：1.