早期要素肠内营养与肠外、肠内阶段性营养治疗急性重症胰腺炎的对比研究

Comparison of early enteral elemental nutrition,and parenteral,enteral stage nutrition in treatment of severe acute pancreatitis

目的:探讨早期肠内要素营养(early enteral elemental nutrition,EEN)与肠外营养(parenteral nutrition,PN)、肠内营养(enteral nutrition,EN)阶段性营养支持对急性重症胰腺炎(Severe acute pancreatitis,SAP)的疗效及临床价值。方法:将45例临床SAP患者随机分为两组,分别接受早期肠内营养(EEN)和阶段性营养支持治疗。观察其血清白蛋白、淀粉酶水平、胃肠功能,比较其并发症、感染率、住院时间和住院费用。结果:两组血清白蛋白水平变化和淀粉酶水平比较无统计学意义(P>0.05),EEN组肠道蠕动恢复较早,且并发症、感染率、住院时间和费用低于阶段性营养支持组(P<0.05)。结论:在SAP的治疗中,72h之内行EEN能减少并发症,改善患者预后。

Objective To explore therapeutic efficacy and clinical value of early elemental enteral nutrition （EEN）,and stage nutrition support of parenteral nutrition （PN） and enteral nutrition（EN） for severe acute pancreatitis （SAP）. Methods Forty-five patients with SAP were randomly divided into two groups,receiving early enteral or stage nutrition support treatment respectively. Serum albumen,amylase level,and intestines and stomach function were observed respectively,and complications,infection rate,hospitalized days,inpatient expenditure were compared. Results There were no difference in serum albumen level and amylase level in two groups （P〉0.05）. Patients treated with EEN early recovered enterokinesia,and complications,infection rate,hospitalized days and inpatient expenditure were lower than that with stage nutrition support （P〈0.05）. Conclusion Patients with SAP,treated with EEN in 72 h,would have fewer complications and better prognosis.