枳椇子对非酒精性脂肪肝大鼠肝脏病理损伤的防治作用

Prevention effect of Zhijuzi on liver pathological injury in rats with non-alcoholic fatty liver

[目的]探讨枳椇子对高脂饮食诱发的非酒精性脂肪肝(NAFLD)大鼠肝组织病理损伤的防治作用。[方法]54只SD雄性大鼠随机分为5组,空白组普通饲料加蒸馏水灌胃,每天1次,其余组均高脂饲料喂养,其中模型组蒸馏水灌胃,易善复组和枳椇子高、低剂量组予相应药物和剂量灌胃,每天1次。90 d后分别观察各组的肝指数及肝组织学改变。[结果]模型组大鼠的肝指数明显高于空白组(P<0.01),肝组织广泛脂肪变,呈中、重度炎症。与模型组比较,高剂量枳椇子组能显著降低大鼠肝指数,并明显改善肝组织炎症程度;易善复组肝指数略低于高剂量枳椇子组,肝组织学无明显改变。[结论]早期、足量地用枳椇子干预对高脂饮食引起的大鼠NAFLD有效。

[Objective]To explore the effect of Zhijuzi on liver pathology of high-fat diet-induced non-alcoholic fatty liver.[Methods]Fifty-four male SD rats were randomly divided into 5 groups,the blank control group administered normal diet plus distilled water once a day,and the remaining groups were fed with high fat diet,in which the model group administered distilled water,Essentiale and low doses of Zhijuzi.The corresponding group of drugs and doses administered,once a day were observed for 90 days,respectively.The group＇s index of the liver and liver histological changes were observed.[Results]The liver index of rats was significantly higher than blank group（P〈0.01）,a wide range of fatty change in liver tissue showed moderate to severe inflammation.Compared with model group,the intervention group of high dose of zhijuzi could significantly reduce the rat liver index,and improve the degree of liver inflammation;Group Essentiale had no significant changes in histology compared with the model group.[Conclusion]The early enough quantities to interfere with Zhijuzi is effective on rats with non-alcoholic fatty liver induced by high fat die.