摘要
目的:研究马来酸咪达唑仑片在汉族健康人体内的药动学。方法:10名汉族健康受试者口服马来酸咪达唑仑片15mg后,用高效液相色谱法测定咪达唑仑血药浓度,用DAS2.0药动学软件拟合药动学参数。结果:受试者单剂量口服马来酸咪达唑仑片后的主要药动学参数分别为Cma(x103.11±26.37)ng·mL-1、tma(x1.52±0.75)h、t1/(22.96±0.77)h、Vz/F(170.08±50.97)L、CL/F(41.05±12.33)L·h-1、AUC0~1(2368.80±103.37)ng·h·mL-1、AUC0~∞(397.29±124.06)ng·h·mL-1。部分受试者的药-时曲线存在双峰现象。结论:咪达唑仑片的药动学参数个体差异较大,临床应用时应注意个体化给药。
OBJECTIVE: To study the pharmacokinetics of midazolam tablets in Hart healthy volunteers. METHODS: 10 healthy volunteers enrolled in the study received a single oral dose of 15 mg midazolam tablets. The plasma concentration was determined by HPLC and the pharmacokinetic parameters were calculated by DAS2.0 software. RESULTS: The main pharmacokinetic parameters were as follows: Cmax(103.11±26.37)ng·mL^-1、tmax(1.52±0.75)h、t1/2(2.96±0.77)h、V2/F(170.08±50.97)L、CL/F(41.05±12.33)L·h^-1、AUC0-12(368.80±103.37)ng·h·mL^-1、AUC0-∞(397.29±124.06)ng·h·mL^-1. There were double peaks in plasma concentration-time profile in part of volunteers. CONCLUSION: Midazolam should be used by means of individualized administration because of significant individual variability in pharmacokinetics.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第10期895-897,共3页
China Pharmacy
基金
全军医学科学技术研究"十一五"计划科技攻关课题资助项目(06G023)