我院241例药品不良反应报告分析

Adverse Drug Reaction Reports in Our Hospital: Analysis of 241 Cases

目的:探讨我院药品不良反应(ADR)发生的特点与一般规律。方法:收集我院2006年1月～2009年6月住院患者伴发的ADR报告241例,分别从患者情况、药品种类、给药途径、累及器官或系统及临床表现等方面进行统计、分析。结果:抗菌药物ADR居多,占69.71%;静脉滴注(西药)引发ADR最多,占71.78%;临床表现以皮肤及其附件损害最多,占50.92%。结论:临床应进行必要的用药干预和指导,加强ADR监测,以减少ADR的发生率。

OBJECTIVE： To study the characteristics and regularity of adverse drug reactions （ADR） occurred in our hospital. METHODS： A total of 241 ADR cases occurred in our hospital form Jan. 2006 to Jan. 2009 were analyzed statistically in respect of patients＇ status, category of drug, route of administration, organs and system involved in ADR and clinical manifestations. RESULTS： Of the total 241 ADR cases, 69.71%ADR cases were induced by antibacterials. 71.78 % ADR cases were induced via intravenous administration. ADR mainly appeared as lesion of skin and appendants （50.92%）. CONCLUSION： It is necessary to intervene and guide clinical use of drug, strengthen the monitoring of ADR and reduce the occurrences of ADR.