葎草化学成分研究

Study on the Chemical Constituents of Humulus scandens

目的：对葎草的化学成分进行研究。方法：采用硅胶柱色谱及凝胶色谱等方法进行分离纯化,并利用理化常数和波谱数据鉴定化合物结构。结果：分离获得7个化合物,其中包括2个甾体类化合物和2个三萜类化合物,分别为木栓酮（Ⅰ）、顺式-细辛醚（Ⅱ）、表木栓醇（Ⅲ）、豆甾-4-烯-3,6-二酮（Ⅳ）、γ-谷甾醇（Ⅴ）、正十六烷酸（Ⅵ）、亚油酸（Ⅶ）。结论：化合物Ⅰ-Ⅴ为首次从该属植物中分离得到,化合物Ⅵ、Ⅶ为首次从该植物中分离得到。

Objective： To study the chemical constituents of Humulus sacndens.Methods： The compounds were isolated by column chromatography on silica gel and Sephadex LH-20.The structures were identified by means of IR,1H-NMR,13C-NMR and MS analyses.Results： Seven compunds were isolated and identified as friedelanone（Ⅰ）,cis-asarone（Ⅱ）,epifriedelanol（Ⅲ）,stigmasta-4-ene-3,6-dione（Ⅳ）,γ-sitosterol（Ⅴ）,n-hexadecanoic acid（Ⅵ）,and linoleic acid（Ⅶ）,respectively.Conclusion：All compounds are isolated from this species for the first time and compounds Ⅰ-Ⅴ are obtained from this genus for the first time.