盾叶薯蓣鲜根茎中甾体皂苷成分研究

Research of Steroidal Saponins from the Fresh Rhizomes of Dioscorea zingiberensis

目的:研究盾叶薯蓣鲜根茎中的甾体皂苷成分,寻找新的生物活性物质。方法:运用正相和反相C18硅胶柱色谱对其甾体皂苷成分进行分离,用MS、NMR等光谱方法进行结构鉴定。结果:从乙醇提取物中分离鉴定了1个甾体化合物,为26-O-β-D-吡喃葡萄糖基-3β,22α,26-三醇-25(R)-呋甾烷-5-烯-3-O-[α-L-吡喃鼠李糖基-(1→4)]-β-D-吡喃葡萄糖苷。结论:该化合物为首次从薯蓣属植物中分离得到。

Objective：To study the steroidal saponins from the fresh rhizomes of Dioscorea zingiberensis and search for new bioactive compounds.Methods：The steroidal saponins were isolated by normal phase silica gel and RP-C18 column chromatography,their chemical structures were elucidated by MS and NMR methods.Results：One steroidal saponin was isolated from EtOH extract of the fresh rhizomes of D.zingiberensis and identified as 26-O-β-D-glucopyranosyl-3β,22α,26-trihydroxy-25（R）-furosta-5-en-3-O-[α-L-rhamnopyranosyl-（1→4）]-β-D-glucopyranoside.Conclusion：This compound is isolated from Dioscorea L.the first time.