黏着斑激酶在乙肝相关性肝细胞癌中的表达

Study on Focal Adhesion Kinase Expression in HBV-Associated Hepatocellular Carcinoma

目的研究黏着斑激酶(FAK)在肝细胞癌,尤其是乙肝病毒相关性肝细胞癌中的作用。方法应用免疫组化法检测肝细胞癌患者67例(其中53例有乙肝病毒感染)。本组手术切除标本均经石蜡包埋,病理检验。结果FAK在HBsAg(+)组的癌组织与HBsAg(-)组癌组织中表达的差异有显著性(P<0.05);在肝癌组织及癌旁组织的表达的差异也有显著性(P<0.05)。结论FAK在乙型肝炎相关性肝细胞癌的发生发展过程中起重要作用,其可能成为治疗乙肝相关性肝细胞癌的治疗靶点。

Objective To investigate whether focal adhesion kinase（FAK） is involved in the progression of human HCC,especially in HBV-associated HCC,as well as to elucidate its clinical significance.Methods We reviewed 67 patients（53 cases with HBV infection） who had undergone liver resection for HCC.Immunohistochemistry analysis for FAK was performed on paraffinembedded tissues.We investigated the correlation between FAK expression and clinical outcome.Results The expression of FAK was differencebetween carcinomas and noncancerous areas（P〈0.05）,and it was stronger in carcinomas with HBsAg（＋） group than that with HBsAg（-） ones（P〈0.05）.Conclusion FAK plays an important role in HCC progression and would be a novel target for HCC therapy.