双环笼状磷酸酯的研究(Ⅱ)——1-硫代-1-磷杂-2,6,7-三氧杂双环[2,2,2]辛烷-4-甲撑衍生物的合成

Study of Caged Bicyclic Phosphates (Ⅱ)——Synthesis of Derivatives of 1-Sulfo-1-Phospha-4-Methylene-2,6,7-Trioxabicyclo[2,2,2]octane

本文合成了1-硫代-1-磷杂-2,6,7-三氧杂双环[2,2,2]辛烷-4-甲撑膦酸酯新化合物11个.发现只有在三乙胺和DMAP同时存在时,1-硫代-1-磷杂-4-羟甲基-2,6,7-三氧杂双环[2,2,2]辛烷方可顺利进行磷酰化得到产物.探讨了DMAP的强有效的催化作用机制.生物初筛表明部分化合物对植物生长有调节作用.

Eleven new compounds with the formula 3 were synthesized by phosphonothiolation reaction of bicyclic phosphate 1 with phosphonothioyl chloide 2 in the presence of DMAP(4-N,N-dimethy-laminopyridine) and Et3N. The outstanding catalysis of DMAP is studied. The structure of compound 3 was confirmed by elemental analysis, IR, 1H NMR and MS. It has been shown that some of these compounds have activities of plant growth regulator by the priliminary biological tests.