苯那普利和尼群地平对高血压病患者肾血流动力学及微量蛋白的影响

Effects of Benazepril and Nitrendipine on Renal Hemodynamics and Microalbuminuria in the Hypertensive Patients

为探讨苯那普利和尼群地平对高血压病患者肾血流动力学和微量蛋白的作用，本文观察了58例高血压病患者服用苯那普利和尼群地平前后肾血浆流量及微量蛋白的变化。结果发现，治疗后苯那普利组患者有效肾血浆流量上升，肾小球滤过分数下降，尿微量蛋白减少（P均〈0．01），尼群地平患者此三项检查无明显变化（P＞0．05）。结果提示，苯那普利对高血压病患者肾功能的改善作用优于尼群地平。

Aim To study the effects of benazepril and ni-trendipine on renal hemodynamics and urinary β2-mi-croglobulin(β2-MG)in the hypertensive patients.Methods A randomized-cross trial comparison of benazepril and nitrendipine in the treatment of 58 hy-pertensive patients divided into two groups for 4 weeks was preformed.The renal hemodynamics and urinary β2-MG were determined in all patients before and after treatment.The urinary β2-MG was measured with ra-dioimmunoassay and renal hemodynamics was detected by means of radionuclide.Results Benazepril not only increased the effective renal plasma flow,but also significantly reduced the filtration fraction and urinary β2-MG(P also<0.01)after treatment.There was no change on the renal hemodynamics and β2-MG after the treatment of ni-trendipine.Conclusion The data indicate that benazepril could improve the renal function better than nitrendipine in the hypertensive patients.