中西医结合治疗狼疮性肾炎肾病综合征临床观察

Clinical Observation on Nephrotic Syndrome of Lupus Nephritis Treated with Integrated Traditional Chinese and Western Medicine

目的 :观察中西医结合治疗狼疮性肾炎肾病综合征的临床疗效。方法 :1 5 5例患者随机分为两组 ,治疗组 (80例 )予以环磷酰胺、激素等及中医辨证治疗 ,对照组 (75例 )予以单纯西医治疗 ,观察两组治疗前后狼疮性肾炎 (LN)活动指标、尿蛋白、血浆白蛋白、血脂的变化及两组在复发率和不良反应发生率上的差异。结果 :治疗组总有效率 95 % ,显著高于对照组(79% ,P <0 0 5 ) ;治疗组在改善LN活动指标、尿蛋白、血浆白蛋白、血脂等方面均优于对照组(P <0 0 5 ) ;治疗组复发率与不良反应发生率分别为 8%和 3 4% ,显著低于对照组 (3 8%和68% ,P <0 0 5 )。结论 :中西医结合治疗较单纯西医治疗狼疮性肾炎肾病综合征有明显优势。

Objective: To observe the clinical effect of integrated traditional Chinese and western medicine (TCM WM) in treating nephrotic syndrome of lupus nephritis (NSLN). Methods: One hundred and fifty five patients of NSLN were randomly divided into the TCM WM group and the control group (treated with western medicine alone). Changes of activity index (AI) of lupus nephritis, urinary protein (UP), plasma albumin (PA), blood lipid (BL) of the patients before and after treatment were observed and compared. And the difference on recurrence rate and adverse reaction rate between the two groups were assessed. Results: The total effective rate of the TCM WM group was 95%, significantly higher than that of the cotrol group (79%, P<0 05). The effect in improving AI, UP, PA and BL of the TCM WM group was superior to that of the control group. The recurrence rate and adverse reaction rate of the former group were 8% and 34% respectively, which was much lower than those of the latter (38% and 68%, P<0 05). Conclusion: TCM WM treatment is obviously superior to treatment with western medicine alone.